Last names starting with "O"
- Class of 2016 Gabriela Ochoa
- Class of 2011 Daniel Olumba
- Amy Oneal
- Class of 1971 Valerie Oneal (formerly Townsend)
- Class of 1994 Rodrigo Oranzco
- Class of 2012 Daniel Ortega
- Karen Osborne
- Class of 1981 Sandra Osborne (formerly Kelley)
- Class of 2009 Edward Osei-Yeboah
- Class of 2016 Fawzieh Osman
- Class of 1971 Steven Osterstrom
- Class of 1985 Paige Ott
- Christopher Ottinger
- Class of 1965 Ronald Overcash
- Class of 2003 Ronnie Overton
- Class of 1973 Becky Owens
- Class of 1970 Steve Owens
- Class of 1997 Terrell Owens
- Class of 2008 Chris Owoa
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